Dysregulated immune responses to infection can result in life-threatening organ dysfunction, known as sepsis or septic shock. Sepsis and septic shock represent a significant burden on healthcare systems, affecting almost 50 million people worldwide every year. Short-term survival from sepsis has improved dramatically in recent years, resulting in increasing numbers of sepsis survivors. Furthermore, sepsis survivors frequently carry a multifactorial burden that can prevent them from regaining their previous state of health. Importantly, 75% of survivors develop complex systemic long-term disorders termed PICS (persistent inflammation, immunosuppression, and catabolism syndrome). Such complex systemic dysregulation frequently persists for months or years and significantly reduces the quality of life (QoL) of sepsis survivors. Although sepsis survivors require detailed medical supervision, current healthcare is inadequate, mainly relying on general practitioners. Moreover, many survivors lack medical supervision altogether, enabling complications to develop unobserved and potentially escalate into serious health issues.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.