Proposed PhD programme aims to bring together the next generation young researchers in a virtual institute to accelerate the development of novel solutions and the fast response to emerging viral outbreaks of the future. Our project provides a first in kind innovative interdisciplinary and translational training in cutting-edge moleclar an biophysical research methodologies. By synergizing the strategic approaches and insights from experts in the fields of plant, animal and human infections, this virtual institute will elucidate molecular mechanisms underlying host-pathogen interactions and the immune response, to provide novel solutions that secure our food and health in the future.
RNA viruses infect a wide range of hosts, ranging from plants and bees to animals and humans. Due to their high mutation and recombination rates, they are particularly likely to evade immunization, host immune response and cross species barriers. Emerging viruses that cross species barriers and infect new hosts may have devastating effects on human lives, either directly via infecting humans or indirectly through impacting animal health and agricultural industries. We therefore urgently need advanced levels of preparedness with which to confront and ultimately control these viruses.
While historically, vaccines have been developed according to the ‘isolate-inactivate-inject’ paradigm, novel advances in X-ray crystallography and NMR spectroscopy have enabled vaccine discovery and development according to the “discover-validate-characterize-apply” paradigm , . Mechanistic insights are needed to better understand viral behavior and immune responses and facilitate the selection of vaccine and antiviral epitopes. Now that all the low-hanging fruit in vaccine development has been picked, researchers skilled in such advanced techniques are necessary to develop the vaccines and antiviral therapies of the future. Considering the complexity and evolutionary smartness of viruses, creativity fueled by cross-pollination of insights from across different host kingdoms is vital to address the current and future threats of these pathogens. This project will therefore deliver a novel generation of researchers that is able to cross these divides and simultaneously translate fundamental research into medical interventions against infectious diseases caused by these and hitherto unknown viruses.